Tuesday, 05 March 2024

 

 

LATEST NEWS 105th Senate Meeting Held at PEC on 5th March, 2024 Governor Shiv Pratap Shukla emphasizes on research on mountain ecosystem Sukhvinder Singh Sukhu dedicates Rs. 73.43 crore development projects at Nerwa Administration gears up for General Elections 2024 Ensure timely completion of development projects- DC Sakshi Sawhney to officers DC Sakshi Sawhney reviews functioning of government cattle pound Indian Actress Janhvi Kapoor Net Worth March 2024 Abu Dhabi Early Childhood Authority Organizes WED Fun Run and Attracts the Participation of 700 Children and Caregivers CM Bhagwant Singh Mann Hails Budget 2024-25 As A Step Forward Towards Carving Out ‘Rangla Punjab’ Through Inclusive, Balanced And Comprehensive Development Of The State To promote organic farming,Harchand Singh Barsat meets farmers at the Farmer's Market Meet Hayer hails Chief Minister and Finance Minister for development-oriented and pro-people Budget Indian Actor Varun Dhawan Net Worth March 2024 Esports Integration: The Convergence of Skill-Based Gaming and Competitive Sports Mahila Morcha's Outreach Initiative- Bjp Punjab's Mahila Morcha Takes Out Nari Shakti Vandan Yatra In Patiala Chief Minister Sukhvinder Singh Sukhu launches Mobile Veterinary Services Mann government committed to welfare of farmers; Rs.2107CR allocated for strengthening irrigation system in state: Chetan Singh Jouramajra CGC Jhanjeri Hosts Prestigious Hackathon 2024, Attracts Global Participation Tamannaah Bhatia earns global recognition after 19 years of hard work in cinema Naveen Patnaik completes straight 24 years as CM of Odisha DDC Doda Harvinder Singh reviews progress of JJM works JJM functionaries receive operations, management training

 

Covid infection before vaccination lowers immunity: Study

XE variant, Omicron Variant, Delta Plus Covid variant, Delta Covid-19 variant, Coronavirus, Health, Research, Study, Researchers, COVID 19, Novel Coronavirus, Fight Against Corona, Covaxin, Covishield, Oxygen, SARS-CoV-2, Sputnik V, Oxygen Plants, Pfizer, Astra Zeneca, Oxygen Concentrator, Remdesivir, Liquid Medical Oxygen, Oximeter
Listen to this article

Web Admin

Web Admin

5 Dariya News

New York , 23 Mar 2023

If you had Covid infection before you took vaccination, chances are that you might have less immunity, claimed a study. Researchers at the Stanford University in the US found that the magnitude and quality of a key immune cell's response to vaccination with two doses of the Pfizer-BioNTech Covid-19 vaccine were considerably lower in people with prior SARS-CoV-2 infection compared to people without prior infection.

In addition, the level of this key immune cell that targets the SARS-CoV-2 spike protein was substantially lower in unvaccinated people with Covid-19 than in vaccinated people who had never been infected.

Importantly, people who recover from SARS-CoV-2 infection and then get vaccinated are more protected than people who are unvaccinated. These findings, which suggest that the virus damages an important immune-cell response, were published in the journal Immunity.

Led by Mark M. Davis, Professor of microbiology and immunology at Stanford's School of Medicine, the researchers designed a very sensitive tool to analyse how immune cells called CD4+ T cells and CD8+ T cells respond to SARS-CoV-2 infection and vaccination.

These cells coordinate the immune system's response to the virus and kill other cells that have been infected, helping prevent Covid. The tool was designed to identify T cells that target any of dozens of specific regions on the virus's spike protein as well as some other viral regions. 

The Pfizer-BioNTech vaccine uses parts of the SARS-CoV-2 spike protein to elicit an immune response without causing infection. The investigators studied CD4+ and CD8+ T-cell responses in blood samples from three groups of volunteers. 

One group had never been infected with SARS-CoV-2 and received two doses of the Pfizer-BioNTech Covid-19 vaccine. The second group had previously been infected with SARS-CoV-2 and received two doses of the vaccine. 

The third group had Covid-19 and was unvaccinated. The researchers found that vaccination of people who had never been infected with SARS-CoV-2 induced robust CD4+ and CD8+ T-cell responses to the virus' spike protein. 

In addition, these T cells produced multiple types of cell-signalling molecules called cytokines, which recruit other immune cells -- including antibody-producing B cells -- to fight pathogens.A

However, people who had been infected with SARS-CoV-2 prior to vaccination produced spike-specific CD8+ T cells at considerably lower levels -- and with less functionality -- than vaccinated people who had never been infected.

Moreover, the researchers observed substantially lower levels of spike-specific CD8+ T cells in unvaccinated people with Covid than in vaccinated people who had never been infected.

Overall, these findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV.

"The new findings highlight the need to develop vaccination strategies to specifically boost antiviral CD8+ T cell responses in people previously infected with SARS-CoV-2," the researchers said.

 

Tags: XE variant , Omicron Variant , Delta Plus Covid variant , Delta Covid-19 variant , Coronavirus , Health , Research , Study , Researchers , COVID 19 , Novel Coronavirus , Fight Against Corona , Covaxin , Covishield , Oxygen , SARS-CoV-2 , Sputnik V , Oxygen Plants , Pfizer , Astra Zeneca , Oxygen Concentrator , Remdesivir , Liquid Medical Oxygen , Oximeter

 

 

related news

 

 

 

Photo Gallery

 

 

Video Gallery

 

 

5 Dariya News RNI Code: PUNMUL/2011/49000
© 2011-2024 | 5 Dariya News | All Rights Reserved
Powered by: CDS PVT LTD