UK scientists have shown that an existing drug may significantly reduce damage after spinal cord injury by blocking the inflammatory response in the spinal cord.The research published in Clinical and Translational Medicine demonstrates that AZD1236, a drug developed by AstraZeneca, can significantly reduce secondary damage caused by the body's response to spinal cord injury (SCI).Researchers at University of Birmingham used animal models to demonstrate that AZD1236 can promote significant nerve regeneration with a dramatic 80 per cent preservation in nerve function following spinal cord compression injury.Crucially, this translated into an 85 per cent improvement in movement and sensation. These dramatic effects were observed following only three days of treatment with AZD1236, starting within 24 hours post-injury.Within three weeks, the AZD1236 treated animals showed unprecedented recovery while controls still showed significant deficits at six weeks post-injury.
One of the key drivers of SCI secondary damage is breakdown of the blood-spinal cord barrier (BSCB). This results in oedema (excess fluid build-up around the spinal cord) and triggers an inflammatory response that can ultimately hinder the healing process and lead to nerve cell death.AZD1236 is a potent and selective inhibitor of two enzymes, MMP-9 and MMP-12, which are implicated in the inflammatory process.The researchers demonstrated that AZD1236 halts SCI-induced oedema and reduces BSCB breakdown and scarring at the site of the injury. They also examined the effect of AZD1236 dosing on MMP-9 and MMP-12 activity in both bloodstream and cerebrospinal fluid which surround the spinal cord."There is currently no reparative drug available for SCI patients, treatments only provide symptomatic relief and do not tackle the underlying molecular mechanisms that cause or contribute to oedema and blood-spinal cord barrier breakdown," said Zubair Ahmed, Professor of Neuroscience at the University's Institute of Inflammation and Ageing.
In the study, the team demonstrated significant suppression of enzyme activity after both oral dosing and intrathecal dosing (injection into the spinal canal). Oral dosing reduced enzyme activity by 90 per cent in serum, and 69-74 per cent in the cerebrospinal fluid. Unsurprisingly, intrathecal injection delivered higher levels (88-90 per cent) of suppression in the cerebrospinal fluid.Further studies showed that AZD1236 suppressed the formation of pro-inflammatory cytokines - molecules that are known to contribute to the development of long-lasting neuropathic pain, which often follows SCI, by 85-95 per cent. AZD1236 was also found to be 82 per cent more effective in alleviating SCI-induced neuropathic pain sensitivity to cold, heat, and touch when compared to currently used pain medications such as pregabalin (Lyrica) and gabapentin."The novel drug could revolutionise the prospects for recovery of SCI patients," Ahmed said