Wednesday, 19 January 2022

 

 

LATEST NEWS DDC Chairperson Udhampur starts work from new office REASI BEEPS: DC Reasi interacts with Home quarantined patients DC reviews progress on civic Projects in Rajouri Township District Administration Srinagar launches anti-encroachment operation at Chhaterhama to retrieve over 350 kanals of Govt land Dr. Arun Kumar Mehta reviews functioning of I&C Department Lt Governor releases book titled "Prakrtik, Vaidik avem Jaivik Kheti" DC inspects ongoing civil works at District Hospital Kishtwar J&K CAMPA formulates rehabilitation plan 2022-23 to restore 17,715 ha degraded forest area ADC takes stock of availability of medicines in DH Ramban Lt Governor reviews progress of restoration, renovation works of Mubarak Mandi Heritage Complex DC Bandipora reviews arrangements for R-Day celebrations Arrangements for Republic Day celebrations finalized in Shopian Dr Shahid Iqbal Choudhary reviews progress on tribal livelihood initiatives MLA priority meeting would go long way in forming realistic plans for development : Jai Ram Thakur First randomisation to deploy manpower for the ensuing Vidhan Sabha elections Biker boy Siddhant Chaturvedi flexes his new cruiser toy National peak of Covid cases may come in 2-3 weeks: SBI Research 'Unproductive' hours are the soul-shaping part of our lives : Priya Bhavani Shankar Willem Dafoe wants to play 'Joker imposter' in movie with Joaquin Phoenix Fast-bowling all-rounders like Venkatesh Iyer are always an asset: KL Rahul Equities settle low on profit booking, rising crude prices; Sensex slips 550 pts

 

How excess sugar consumption causes fatty liver

  Health, Study, Mandi, Research, Researchers, Non-Alcoholic Fatty Liver Disease, NAFLD, fatty liver, NPCDCS

Web Admin

Web Admin

5 Dariya News

Mandi , 14 Jun 2021

A team of researchers from IIT Mandi has identified the underlying biochemical relationship between the consumption of excessive sugar and the development of afatty liver', medically known as Non-Alcoholic Fatty Liver Disease (NAFLD).NAFLD is a condition in which excess fat deposits in the liver. The disease starts silently, with no overt symptoms for as much as two decades. If left untreated, the excess fat can irritate the liver cells, resulting in scarring of the liver (cirrhosis), and in advanced cases, can even lead to liver cancer. The treatment of advanced stages of NAFLD is difficult.One of the causes for NAFLD is the overconsumption of sugar -- both table sugar (sucrose) and other forms of carbohydrates. The consumption of excess sugar and carbohydrates causes the liver to convert them into fat in a process called hepatic De Novo Lipogenesis or DNL, which leads to fat accumulation in the liver.The molecular mechanisms that increase hepatic DNL due to overconsumption of sugar, which is is key to developing therapeutics for the NAFLD, have not been clear yet, said lead scientist Prosenjit Mondal, Associate Professor, School of Basic Sciences, IIT Mandi.The team used a complementary experimental approach involving mice models, and identified the unknown link between the carbohydrate-induced activation of a protein complex called NF-KB and increased DNL.

"Our data indicates that the sugar-mediated shuttling of hepatic NF-KB p65 reduces the levels of another protein, sorcin, which in turn activates liver DNL through a cascading biochemical pathway," explained Mondal. The findings are published in the Journal of Biological Chemistry.The team showed that drugs that can inhibit NF-KB can prevent sugar-induced hepatic fat accumulation. They have also shown that the knockdown of sorcin reduces the lipid-lowering ability of the NF-KB inhibitor.The finding that NF-KB plays a key role in lipid accumulation in the liver opens up a new avenue of therapeutics for NAFLD. NF-KB also plays a role in other diseases that involve inflammation, such as cancer, Alzheimer's disease, atherosclerosis, IBS, stroke, muscle wasting and infections.The research comes at a time when India has included NAFLD in the National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS).India is the first country in the world to identify the need for action on NAFLD and with good reason. The prevalence of NAFLD in India is about 9 per cent to 32 per cent of the population, with the state of Kerala alone having a prevalence of 49 per cent and a staggering 60 per cent prevalence among obese school-going children.The study has conclusively shown that excessive sugar intake leads to a fatty liver. This should offer incentive to the public to reduce sugar intake to stop NAFLD in its early stages, the team said.

 

Tags: Health , Study , Mandi , Research , Researchers , Non-Alcoholic Fatty Liver Disease , NAFLD , fatty liver , NPCDCS

 

 

related news

 

 

 

Photo Gallery

 

 

Video Gallery

 

 

5 Dariya News RNI Code: PUNMUL/2011/49000
© 2011-2022 | 5 Dariya News | All Rights Reserved
Powered by: CDS PVT LTD