Tuesday, 28 September 2021

 

 

LATEST NEWS Union MoRTH Nitin Gadkari, Lt Governor lay foundation for four National Highway Projects worth Rs 3612 Cr Two-day visit of Union Minister for I&B to Ganderbal concludes Rs 200 Cr. allotted for Development of sports infrastructure on modern pattern in U.T of J&K : Anurag Thakur Ramdas Athawale takes stock of implementation of social welfare schemes in Jammu Union Minister of State Tribal Affairs Renuka Singh visits District Kulgam Union MoS Road Transport and Highways, Civil Aviation Dr. V. K. Singh visits Anantnag Union MoS, Tribal Affairs Renuka Singh interacts with DDC, BDC members, other PRI representatives at Kulgam Union Minister of State for Finance inaugurates various development projects in Jammu Union MoS Jal Shakti, Tribal Affairs, Bishweswar Tudu concludes visit to Kishtwar Lt Governor visits “The Paradise Fest” organized to celebrate World Tourism Week Charanjit Singh Channi Asks Administrative Secretaries To Prepare 100 Days Roadmap To Ensure Holistic Development Of State Charanjit Singh Channi Calls Emergency Meeting On Farmers' Issues In Wake Of 'Bharat Bandh' Call Given By Samyukt Kisan Morcha Charanjit Singh Channi Curtails Security Of VVIPs SSP Pulwama Gulam Jeelani Wani, assume charge, held introductory meeting with Visits various posts of district police Pulwama Parliamentarian Delegation arriving to interact with common people in Kashmir Assam's highest civilian award for national integration to be conferred by V-P Naidu RSS statement on Amazon irrelevant : Randeep Singh Surjewala India-US enhanced ties to boost research, health management : Bharati Pravin Pawar Shafali Verma and Radha Yadav sign up for Sydney Sixers in WBBL England cricketer Moeen Ali retires from Test cricket Don't see that aggressiveness in this Mumbai Indians side : Zaheer Khan

 

Moderna's Covid vax shows great result in monkeys

Web Admin

Web Admin

5 Dariya News

New York , 29 Jul 2020

Pharmaceutical company Moderna's Covid-19 vaccine, which is currently in clinical trials, has shown successful results in monkeys.Two doses of an experimental vaccine known as mRNA-1273 induced robust immune responses and rapidly controlled the Covid-19 in the upper and lower airways of Monkeys exposed to SARS-CoV-2, the National Institute of Allergy and Infectious Diseases (NIAID) reported.In this study, published in the New England Journal of Medicine, three groups of eight rhesus macaques (monkeys) received two injections of 10 or 100 micrograms of mRNA-1273 or a placebo.Injections were spaced 28 days apart. Vaccinated monkeys produced high levels of neutralizing antibodies directed at the surface spike protein used by SARS-CoV-2 to attach to and enter cells."Notably, animals receiving the 10-micrograms or 100-micrograms dose vaccine candidate produced neutralizing antibodies in the blood at levels well above those found in people who recovered from Covid-19," the researchers wrote.The experimental vaccine also induced Th1 T-cell responses but not Th2 responses, they added.According to the study, induction of Th2 responses has been associated with a phenomenon called vaccine-associated enhancement of respiratory disease (VAERD).Vaccine-induced Th1 responses have not been associated with VAERD for other respiratory diseases.

In addition, the experimental vaccine-induced T follicular helper T-cell responses that may have contributed to the robust antibody response.Four weeks after the second injection, all the monkeys were exposed to SARS-CoV-2 via both the nose and the lungs.Remarkably, after two days, no replicating virus was detectable in the lungs of seven out of eight of the monkeys in both vaccinated groups, while all eight placebo-injected animals continued to have to replicate virus in the lung.Moreover, none of the eight monkeys vaccinated with 100 micrograms of mRNA-1273 had detectable virus in their noses two days after virus exposure.This is the first time an experimental Covid-19 vaccine tested in nonhuman primates has been shown to produce such rapid viral control in the upper airway, the investigators noted."A Covid-19 vaccine that reduces viral replication in the lungs would limit disease in the individual while reducing shedding in the upper airway would potentially lessen the transmission of SARS-CoV-2 and consequently reduce the spread of disease," they added.Meanwhile, Moderna has also begun a phase-3 clinical trial to evaluate mRNA-1273 vaccine, designed to protect against Covid-19 virus, which includes 30,000 participants the US clinical research sites, who do not have Covid-19.

 

Tags: Coronavirus , COVID 19 , Novel Coronavirus , India Fights Corona , Fight Against Corona , Corona Virus Updates , Moderna , Covid-19 vaccine , New York , National Institute of Allergy and Infectious Diseases , NIAID

 

 

related news

 

 

Photo Gallery

 

 

Video Gallery

 

 

5 Dariya News RNI Code: PUNMUL/2011/49000
© 2011-2021 | 5 Dariya News | All Rights Reserved
Powered by: CDS PVT LTD