Saturday, 03 December 2022

 

 

LATEST NEWS Punjab Police's AGTF Arrests Lawrence Bishnoi Gang Member From Dhakoli; Recovers 20 Pistols, Innova Car Chief Secretary Vijay Kumar Janjua Directs To Focus On The Coverage Of Children Under Aadhaar Now, Horticulture Experts Just A Call Away Punjab Police Foil Major Heroin Smuggling Bid Through Indo-Pak Border; 5.6 Kg Heroin, Hexacopter Drone Recovered We want to build the biggest league outside India : Graeme Smith Litton Kumer Das to lead Bangladesh in upcoming ODI series against India Suryakumar Yadav will someday win a World Cup for Team India : Brett Lee Free yoga classes to continue at all costs, announces Arvind Kejriwal WhatsApp rolls out disappearing messages shortcut on Android beta National Conference on Innovative Trends in Engineering Technology concludes at GCET Jammu DC Ramban Mussarat Islam reviews progress of work on NH-44 Four laning project Committee on Land Use approves 12 cases in Doda Modern Youth Innovation Centre coming up in Ghat soon DDC Chairman Dhananter Singh Kotwal launches work of JJM Water Supply Scheme at village Rainda DDC Rajouri Vikas Kundal reviews performance of PMGSY MVD, Health Department organise free medical camp for operators of commercial vehicles NCSC Chairman Vijay Sampla asks Cochin Port authority and Cochin Shipyard limited to redress issues of SC employees Every unemployed youth will get job, contractual employees to be regularised in Gujarat : Bhagwant Mann Harbhajan Singh ETO directs officials of PWD to speed up the ongoing development works Governor Rajendra Vishwanath Arlekar inaugurates National Conference on Digital Crime and Forensic Science Director Agriculture Chowdhury Mohammad Iqbal reviews working scenario of Agriculture Law Enforcement Agency

 

HIV drug may be a potential treatment for dementia: Study

Health, Study, New York, Research, Researchers, World News, HIV Drug, Dementia

Web Admin

Web Admin

5 Dariya News

New York , 31 May 2022

US researchers have found an HIV drug that could help reverse memory loss in middle age, in a possible early intervention for dementia. Human brains rarely record single memories - instead, they store memories into groups so that the recollection of one significant memory triggers the recall of others connected by time. 

As we age, however, our brains gradually lose this ability to link related memories. Now, University of California-Los Angeles (UCLA) researchers have discovered a key molecular mechanism behind memory linking. They've also identified a way to restore this brain function in middle-aged mice with an US Food and Drug Administration-approved drug that achieves the same thing. 

Maraviroc, which was approved in 2007 for the treatment of HIV infection, was found to suppress a gene in the brains of mice that reduced memory recall. The finding, published in Nature, suggests that maraviroc could be used off-label to help restore middle-aged memory loss in mice, as well as reverse the cognitive deficits caused by HIV infection. 

"When we gave maraviroc to older mice, the drug duplicated the effect of genetically deleting CCR5 from their DNA," said Alcino Silva, Professor of neurobiology and psychiatry at the David Geffen School of Medicine at UCLA. "The older animals were able to link memories again," he added. The team focused on a gene called CCR5 that encodes the CCR5 receptor - the same one that HIV hitches a ride on to infect the brain cell and cause memory loss in AIDS patients. 

Earlier research had demonstrated that CCR5 expression reduced memory recall. In the current study, Silva and team found that boosting CCR5 gene expression in the brains of middle-aged mice interfered with memory linking. The animals forgot the connection between the two cages. When the scientists deleted the CCR5 gene in the animals, the mice were able to link memories that normal mice could not. 

"Our next step will be to organise a clinical trial to test maraviroc's influence on early memory loss with the goal of early intervention," said Silva. "Once we fully understand how memory declines, we possess the potential to slow down the process."

 

Tags: Health , Study , New York , Research , Researchers , World News , HIV Drug , Dementia

 

 

related news

 

 

 

Photo Gallery

 

 

Video Gallery

 

 

5 Dariya News RNI Code: PUNMUL/2011/49000
© 2011-2022 | 5 Dariya News | All Rights Reserved
Powered by: CDS PVT LTD