Sunday, 14 August 2022



LATEST NEWS MLA Madan Lal Bagga & DC take stock of Aam Aadmi Clinic to be inaugurated by Punjab CM on Aug 15 BJP intensified the campaign to hoist the Tringa from house to house in the phases of the city Uni: Ranjit Bawa Unveils Captivating Poster & Release Date Of New Single Track One MLA - One Pension' will save Rs 100 crore taxpayers money in 5 years : Malvinder Singh Kang Why Mindy Kaling says she could never write 'Euphoria' Bangladesh appoint Shakib Al Hasan as T20 captain until 2022 World Cup, name Asia Cup squad If there's no competition then nobody would want to improve themselves : Sudhanshu Pandey Pretoria Capitals sign SA pace duo Anrich Nortje, Migael Pretorius for CSA T20 League Simi Singh replaces Andy McBrine in Ireland's squad for last two T20I against Afghanistan Idris Elba shares moment when a bat interrupted steamy shower with wife Raju Srivastava's family says his condition is stable Deputy Commissioner Surabhi Malik inspects full dress rehearsal of 75th state level Independence Day Function Qatar World Cup no event 'for the average fan': Germany coach Hansi Flick Ayushmann Khurrana on rising Covid cases: 'Nazar lag gayi hai hum sab ko' Pracheen Chauhan to be seen in a ghazal titled 'Rakh Lo' China issues highest alert for heat Delhi reports 5th monkeypox case Nawa Nawa Pyaar: Gippy Grewal Announces Another Song For His Upcoming Film Yaar Mera Titliaan Warga Canadian Open : Simona Halep topples Coco Gauff, Haddad Maia extends run If I was Chris Lynn, I would have taken CA to court for wanting to play in the UAE : Ian Chappell Urmila Matondkar says no one can take their eyes off Govinda when he comes on screen


HIV drug may be a potential treatment for dementia: Study

Health, Study, New York, Research, Researchers, World News, HIV Drug, Dementia

Web Admin

Web Admin

5 Dariya News

New York , 31 May 2022

US researchers have found an HIV drug that could help reverse memory loss in middle age, in a possible early intervention for dementia. Human brains rarely record single memories - instead, they store memories into groups so that the recollection of one significant memory triggers the recall of others connected by time. 

As we age, however, our brains gradually lose this ability to link related memories. Now, University of California-Los Angeles (UCLA) researchers have discovered a key molecular mechanism behind memory linking. They've also identified a way to restore this brain function in middle-aged mice with an US Food and Drug Administration-approved drug that achieves the same thing. 

Maraviroc, which was approved in 2007 for the treatment of HIV infection, was found to suppress a gene in the brains of mice that reduced memory recall. The finding, published in Nature, suggests that maraviroc could be used off-label to help restore middle-aged memory loss in mice, as well as reverse the cognitive deficits caused by HIV infection. 

"When we gave maraviroc to older mice, the drug duplicated the effect of genetically deleting CCR5 from their DNA," said Alcino Silva, Professor of neurobiology and psychiatry at the David Geffen School of Medicine at UCLA. "The older animals were able to link memories again," he added. The team focused on a gene called CCR5 that encodes the CCR5 receptor - the same one that HIV hitches a ride on to infect the brain cell and cause memory loss in AIDS patients. 

Earlier research had demonstrated that CCR5 expression reduced memory recall. In the current study, Silva and team found that boosting CCR5 gene expression in the brains of middle-aged mice interfered with memory linking. The animals forgot the connection between the two cages. When the scientists deleted the CCR5 gene in the animals, the mice were able to link memories that normal mice could not. 

"Our next step will be to organise a clinical trial to test maraviroc's influence on early memory loss with the goal of early intervention," said Silva. "Once we fully understand how memory declines, we possess the potential to slow down the process."


Tags: Health , Study , New York , Research , Researchers , World News , HIV Drug , Dementia



related news




Photo Gallery



Video Gallery



5 Dariya News RNI Code: PUNMUL/2011/49000
© 2011-2022 | 5 Dariya News | All Rights Reserved
Powered by: CDS PVT LTD