Wednesday, 08 December 2021

 

 

LATEST NEWS Charanjit Singh Channi Announces Heritage Street For Talwandi Sabo Charanjit Singh Channi Calls On Jathedar Sri Akal Takht Sahib Giani Harpreet Singh India announce 18-man squad for S Africa Tests, Rohit Sharma named ODI captain India players Mayank Agarwal and Ravichandran Ashwin make big progress in ICC Rankings Women's Asian Champions Trophy Hockey: India player tests Covid-positive, match vs Korea cancelled Usain Bolt's wish comes true, gets invited for T20 League Ashes, 1st Test: Rain ends play early after Cummins leads Australia in skittling out England for 147 UEFA Champions League: Real Madrid seal group leadership as Atletico book place in last-16 Novak Djokovic confirmed for ATP Cup; drops hint he will compete at Australian Open As England slump in opening Ashes Test, Ian Chappell says Joe Root not much of a captain Jude Bellingham fined by German FA for referee comments The Ashes, 1st Test: Pat Cummins leads the way as Australia skittle out England for 147 Winter Olympics: IOC does not foresee any situation to postpone Beijing 2022 Games 'Bigg Boss 15': Ex-contestant Neha Bhasin cheers for friend Shamita Shetty Ankita Lokhande injured ahead of her wedding, advised bed rest Manish Tewari seeks withdrawal of notification extending BSF jurisdiction in Punjab Jagat Prakash Nadda visits Swarnim Himachal Kala Mahotsav Jai Ram Thakur presided over a State Working Committee and Training programme "Punjab Minimum Wages Advisory Board" meets to fix minimum wages for workers 'KatVic' wedding: Wikipedia changes reversed after Vicky, Katrina named as spouses Ashwin Kumar Lakshmikanthan says he often dozes off during narration, directors livid

 

Lab-grown 'mini brains' to pave way for dementia treatment

Health, Study, New York, Research, Researchers, World News

Web Admin

Web Admin

5 Dariya News

London , 22 Oct 2021

UK researchers have developed 'mini brains' that allow them to study a fatal and untreatable neurological disorder causing paralysis and dementia.This is not the first time scientists have grown mini brains from patients with neurodegenerative diseases, but most efforts have only been able to grow them for a relatively short time frame.For the first time, scientists at the University of Cambridge were able to grow these small organ-like models (organoids) of the brain for almost a year.A common form of motor neurone disease, amyotrophic lateral sclerosis, often overlaps with frontotemporal dementia (ALS/FTD) and can affect younger people, occurring mostly after the age of 40-45. These conditions cause devastating symptoms of muscle weakness with changes in memory, behaviour, and personality.In findings, published in the journal Nature Neuroscience, the Cambridge team reported growing these models for 240 days from stem cells harbouring the commonest genetic mutation in ALS/FTD, which was not previously possible -- and in unpublished work, the team has grown them for 340 days."Neurodegenerative diseases are very complex disorders that can affect many different cell types and how these cells interact at different times as the diseases progress," said Dr Andras Lakatos, from the Cambridge's Department of Clinical Neurosciences.

"To come close to capturing this complexity, we need models that are more long-lived and replicate the composition of those human brain cell populations in which disturbances typically occur, and this is what our approach offers. Not only can we see what may happen early on in the disease -- long before a patient might experience any symptoms -- but we can also begin to see how the disturbances change over time in each cell," Lakatos added.While organoids are usually grown as balls of cells, the team generated patient cell-derived organoid slice cultures in laboratory. This technique ensured that most cells within the model could receive the nutrients required to keep them alive.Using this approach, the team observed changes occurring in the cells of the organoids at a very early stage, including cell stress, damage to DNA, and changes in how the DNA is transcribed into proteins. These changes affected those nerve cells and other brain cells known as astroglia, which orchestrate muscle movements and mental abilities.Besides understanding disease development, organoids can also be a powerful tool for screening potential drugs.The team showed that drug GSK2606414 was effective at relieving common cellular problems in ALS/FTD, including the accumulation of toxic proteins, cell stress and the loss of nerve cells, hence blocking one of the pathways that contributes to disease.

 

Tags: Health , Study , New York , Research , Researchers , World News

 

 

related news

 

 

 

Photo Gallery

 

 

Video Gallery

 

 

5 Dariya News RNI Code: PUNMUL/2011/49000
© 2011-2021 | 5 Dariya News | All Rights Reserved
Powered by: CDS PVT LTD