Wednesday, 27 October 2021



LATEST NEWS Administrative Council extends relief under SRO 43 to the next of kin of violence victims Dr. Arun Kumar Mehta reviews implementation of Business Reform Action Plan /Ease of Doing Business reforms in J&K Advisor Farooq Ahmad Khan reviews crop losses due to recent rains, hailstorm in Jammu division Vigilance awareness week: Integrity Pledge held across Kashmir Officer Trainees of Indian Information Service call on JDIPR, Jammu Mayor JMC flags off walkthone to promote Heritage tourism Corridor of Jammu City J&K IMPARD observes Vigilance Awareness Week at Jammu, Srinagar Congress government betrayed unemployed of Punjab at every step : Harpal Singh Cheema SAD To Move Assembly Resolution To Direct State For A Cabinet Decision To Block Central Moves On Farm Laws And BSF Punjab Cabinet Decides To Summon Special Assembly Session On November 8 CM lays foundation stone of Sports Stadium in memory of farmers who lost their lives during farm laws agitation Charanjit Singh Channi Announces To Scrap 40,000 Cases Of Vat Against Industrialists And Traders Will Launch New Party Once EC Clears Name & Symbol : Captain Amarinder Singh Captain Amarinder Singh To Lead Delegation Of Non-Political Agriculture Experts To Meet Shah On Farmers’ Stir Captain Amarinder Singh Slams Punjab Govt For Being In Denial Mode Over Growing Security Threat Why Rajkummar Rao is spooked by Archana Puran Singh Neha Dhupia shares breastfeeding pic: 'Freedom to feed' 'KGF' star Yash floors all with his humility at 'Bajarangi 2' event Chiranjeevi to bear expenses for fan's cancer treatment Diana Penty's 'Adbhut' sneak peek from her shoot 'Tadap' trailer featuring Ahan Shetty, Tara Sutaria out Wednesday


Human mini-lungs in lab to help develop new treatments for Covid

Delta Plus Covid variant, Delta Covid-19 variant, Coronavirus, Health, Research, Study, Researchers, COVID 19, Novel Coronavirus, Fight Against Corona, Covaxin, Covishield, Oxygen, Oxygen Cylinders, SARS-CoV-2, Sputnik V, Oxygen Plants, Pfizer, Astra Zeneca, Oxygen Concentrator, Remdesivir, Oxygen supply, Liquid Medical Oxygen, Oximeter

Web Admin

Web Admin

5 Dariya News

New York , 01 Sep 2021

The US researchers have grown mini human lungs in lab dishes using adult stem cells, featuring all types of cells that make up the human organ, allowing for testing of new treatments for respiratory diseases, including Covid-19.Attempts to grow adult human lungs have historically failed because not all of the cell types survived.The first adult human "lung-in-a-dish" models, described in the journal eLife, are also known as lung organoids and represent all cell types.The SARS-CoV-2 infection of the lung organoids replicates real-world patient lung infections, and reveals the specialised roles various cell types play in infected lungs, said the team at the University of California-San Diego."This human disease model will now allow us to test drug efficacy and toxicity, and reject ineffective compounds early in the process, at 'Phase 0', before human clinical trials begin," said Pradipta Ghosh, Professor, at UC San Diego School of Medicine.The stem cell scientists reproducibly developed three lung organoid lines from adult stem cells derived from human lungs that had been surgically removed due to lung cancer. With a special cocktail of growth factors, they were able to maintain cells that make up both the upper and lower airways of human lungs, including specialized alveolar cells known as AT2.

By infecting the lung organoids with SARS-CoV-2, the team discovered that the upper airway cells are critical for the virus to establish infection, while the lower airway cells are important for the immune response. Both cell types contribute to the overzealous immune response, sometimes called a cytokine storm that has been observed in severe cases of Covid-19.A computational team validated the new lung organoids by comparing their gene expression patterns -- which genes are "on" or "off" -- to patterns reported in the lungs of patients who succumbed to the disease, and to those that they previously uncovered from databases of viral pandemic patient data.Whether infected or not with SARS-CoV-2, the lung organoids behaved similar to real-world lungs. In head-to-head comparisons using the same yardstick (gene expression patterns), the researchers showed that their adult lung organoids replicated Covid-19 better than any other current lab model.Other models, for example foetal lung-derived organoids and models that rely only on upper airway cells, allowed robust viral infection, but failed to mount an immune response."Our lung organoids are now ready to use to explore the uncharted territory of Covid-19, including post-Covid complications, such as lung fibrosis," said Soumita Das, PhD, associate professor of pathology at UC San Diego."We have already begun to test drugs for their ability to control viral infection -- from entry to replication to spread -- the runaway immune response that is so often fatal, and lung fibrosis," she added.


Tags: Delta Plus Covid variant , Delta Covid-19 variant , Coronavirus , Health , Research , Study , Researchers , COVID 19 , Novel Coronavirus , Fight Against Corona , Covaxin , Covishield , Oxygen , Oxygen Cylinders , SARS-CoV-2 , Sputnik V , Oxygen Plants , Pfizer , Astra Zeneca , Oxygen Concentrator , Remdesivir , Oxygen supply , Liquid Medical Oxygen , Oximeter



related news




Photo Gallery



Video Gallery



5 Dariya News RNI Code: PUNMUL/2011/49000
© 2011-2021 | 5 Dariya News | All Rights Reserved
Powered by: CDS PVT LTD