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NEWS FLASH Tourist Places of Kashmir : Betaab Valley Also known as Switzerland of India JK coming up as golfing capital of the country : Sarmad Hafeez Dr. Jitendra Singh conducts extensive tour of Khonmoh, Srinagar Good Health and Development Go Hand in Hand : Mansukh Mandaviya Lt Governor hands over Individual and Community Forest Rights certificates to members of Tribal Communities of Jammu Division Former legislators call on Lt Governor, highlight issues of public importance Lt Governor, Manoj Sinha honours Tokyo Paralympics Participants J&K JA organizes training on “Personality Development, a Pursuit of Justice, Leadership role of a Judge as captain of ship in Trial Court” Promoting Paradise : Srinagar hosts Lions Club MICE event Roll Ball Association delegation calls on Advisor Farooq Khan DDC Chairperson Udhampur gives away motorised tricycles to specially abled persons Deputy Commissioner Udhampur, Indu Kanwal Chib listens to issues of local artisans at Panchayat Sansoo J&K Bank CMD meets PHDCCI delegation First ever coordination meeting held at District Court Complex Ganderbal Fit India Movement : DC Ramban flags off Patnitop Hill Marathon DC Ganderbal inspects progress on various School Education projects DDC Anantnag , Dr. Piyush Singla inaugurates inter-zonal tournaments Divisional Commissioner Kashmir, Pandurang Kondbara Pole for 100% vaccination of staff in govt, private offices Divisional Commissioner Kashmir, Pandurang Kondbara Pole conducts site visit of Srinagar riverfront project Divisional Commissioner Kashmir, Pandurang Kondbara Pole invokes Imams, Khateebs for CAB enforcement in Srinagar DC Kupwara, Imam Din visits fire victims at Nagri Malpora


ViroVax's adjuvant to enhance response to Bharat Biotech's Covaxin

Web Admin

Web Admin

5 Dariya News

Hyderabad , 05 Oct 2020

Leading pharmaceutical company Bharat Biotech will use Kansas-based ViroVax's adjuvant Alhydroxiquim-II to boost the immune response to its coronavirus vaccine Covaxin.Covaxin is an inactivated vaccine derived from a strain of SARS-CoV-2 virus, isolated at the National Institute of Virology (NIV), Pune.The inactivated virus is formulated with ViroVax's adjuvant to produce the vaccine candidate, under a licensing agreement.Currently, Bharat Biotech is conducting Phase II clinical trials with Covaxin, approved by the Drugs Controller General of India (DGCI).Explaining the need for adjuvants, components which enhance the effectiveness of medical treatment, Bharat Biotech Chairman and MD Krishna Ella said adjuvants induce greater antibody responses to vaccine antigens, resulting in long-term protection against pathogens."Adjuvants also enhance the sustainability of the global vaccine supply on account of their antigen-sparing effect. Our partnership with ViroVax resonates with Bharat Biotech's relentless efforts towards developing safe and effective vaccines coupled with long-term immunity," said Ella.

According to Ella, aluminium hydroxide adjuvant, widely used in the development of SARS-CoV-2 vaccines, is known to induce Th2-based response, which is important for the eradication of extracellular parasites and bacterial infection."The Th2-based response has a theoretical risk of vaccine associated enhanced respiratory diseases (VAERD or ADE). We have used Imidazoquinoline class of adjuvants (TLR7/8 agonists), which are known to induce Th1-based response which further reduces the risk of ADE (Anti-Body Dependent Enhancement)," he said .He said in Bharat Biotech's preclinical studies and animal challenge models on Syrian Hamster and Rhesus Macaques, Covaxin induced Th1-response due to the use of Algel-IMDG as an adjuvant.Meanwhile, Sunil David from ViroVax said the Kansas company is delighted to partner with Bharat Biotech, a collaboration facilitated by the National Institute of Health.


Tags: Coronavirus , COVID 19 , Novel Coronavirus , India Fights Corona , Fight Against Corona , Corona Virus Updates , Social Distancing , Coronavirus Epidemic , Coronavirus Pandemic , Corona virus threat , Corona Outbreak , Covid-19 pandemic , Hyderabad , Drugs Controller General of India , DGCI , National Institute of Virology , NIV , Pune , Bharat Biotech



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