David Marshall, a 54 year old gentleman suffered from serious Liver problems and came to Kumaran Hospitals, where he was diagnosed with Liver Failure and Liver Cancer. The problem was very serious and it was clearly evident that only a Liver Transplant could save his life.Since the patient was very ill, a unique solution was put forth in the case of David Marshall, where his son, whose blood group did not match his father’s, agreed to donate his liver. After a detailed team discussion in the best interest of the patient it was decided to go ahead with liver transplantation after desensitisation’ of the recipient blood by removing antibodies that can cause severe rejection. This is called ABO incompatible liver transplantation, a lifesaving surgery.The health status of the patient was monitored closely and the transplantation was carried out successfully in Kumaran Hospitals, Kilpauk, Chennai by the team lead by Prof Mohamed Rela from Dr Rela Institute, Chromepet, Chennai. After the successful transplant surgery, the patient recovered well in the ICU and was shifted to the regular ward from where he was discharged after complete recovery.